A/HRC/45/12/Add.4 (n) Develop time bound plans to urgently reduce pesticide and toxic industrial chemical use and exposure, including: (…) (ii) Phase out the use of highly hazardous pesticides, including glyphosate and atrazine; 46. Anvisa is finalizing the toxicological re-evaluation of glyphosate. The agency has carried out the analysis of toxicological studies and monitoring data for residues and intoxications and issued a re-evaluation preliminary Technical Note as a subsidy for the decision to be made. 47. Anvisa's decision was submitted to public consultation (CP 613, of February 28, 2019), together with the Collegiate Board's Resolution Proposal on the maintenance of the active ingredient glyphosate in agrochemical products in the country and the measures resulting from its toxicological evaluation7. 48. It should be noted that the analysis methodology used by Anvisa for the toxicological assessment of pesticides is in line with the best international regulatory practices. The American (USEPA), Canadian (PMRA), and European (EFSA) regulatory agencies reached the same conclusions as Anvisa's public consultation proposal and proposed maintaining glyphosate-based products in their countries. 49. In this regard, it is worth mentioning that glyphosate is not prohibited in any country to date. 50. The risk assessment for workers, operators, residents, and passers-by carried out by Anvisa pointed out, in the mentioned Technical Note, the need to adopt measures to ensure higher safety for people who are in contact with products containing glyphosate, such as the use personal protective equipment, inclusion of safety information in package inserts and monographs; prohibition of application rates and formulation types; and education and management programs for users of these products. 51. The glyphosate reevaluation process is in its final stage and should be resolved soon by the Anvisa Collegiate Board (Dicol). The decision will be published through a Resolution of the Collegiate Board of Directors in the Federal Official Gazette, which will complete Anvisa's toxicological reassessment process for this active ingredient and define the risk mitigation measures to be adopted. 52. Regarding atrazine, this active pesticide ingredient has not been approved in Europe since 2004 due to environmental risk, but not to health. It was concluded that there is no evidence that the limit of 0.1 μg / L in groundwater is not exceeded. 53. In Brazil, the active ingredient is authorized for use in pre-emergence and postemergence of weed plants in pineapple, sugar cane, corn, millet, pine, rubber, sisal, and sorghum crops. This ingredient was monitored in 14,958 food samples from 2013 to 2018, having been detected in 11 samples (0.07%). 54. Given the above, Anvisa's role in the toxicological assessment carried out before the registration of pesticide products in Brazil remains clear, following transparent criteria and in line with the best scientific and regulatory practices adopted internationally. It is also worth mentioning the Agency's active role in post-marketing actions for these products, through the evaluation of data from the pesticide residue-monitoring program and the toxicological reassessment of active ingredients used in agriculture. 55. Also, concerning improving regulatory science on the analysis of pesticides and the like, IBAMA has intensified its efforts through five projects: I - Pesticide monitoring in environmental matrices: surface water, rainwater and soil; 7 8 All documents are available and accessible in http://portal.anvisa.gov.br/consultaspublicas#/visualizar/391760 .

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