A/HRC/21/21 capacity-building efforts should be support for groups that are particularly vulnerable to discrimination or to adverse effects arising from business activities, including indigenous peoples, migrants, women and children. It is especially critical that the capacity of human rights defenders to carry out their work in the context of the adverse impact of business activities be strengthened, in particular with regard to access to effective remedies. 69. To enable comprehensive capacity-building and the capturing of lessons learned by different actors, enhanced knowledge management is required. At the current time there is no global repository of information on patterns of business-related human rights impact and responses by States and business, as well as other stakeholders, to address such an impact. 70. The establishment of a global database could facilitate record-keeping of the implementation of the Guiding Principles by States and business enterprises, as well as by other stakeholders, including information on State initiatives and processes, corporate policies and practices, and the use of accountability mechanisms for affected stakeholders. 71. The institutionalization of a global repository on business and human rights within the United Nations, in collaboration with external partners in both design and informationgathering and management phases, would improve the availability of comprehensive information to all stakeholders, with a view to promoting the further dissemination and implementation of the Guiding Principles and to ensure systematic tracking of challenges and lessons learned. The information collected in the context of the universal periodic review, and by treaty bodies and special procedures could also be included in such a database. 72. There is also scope for use of existing platforms, such as the United Nations Practitioners’ Portal on Human Rights-Based Approaches to Programming, and the online discussion forum for the Human Rights Policy Network, HuriTALK. The integration of human rights and business can contribute to both awareness-raising of the Guiding Principles and an emerging body of lessons learned and practices in promoting their implementation. 73. With regard to business practice, the Global Compact provides a key platform for sharing knowledge in the implementation of members’ commitments. Through the Global Compact Human Rights Working Group, the Global Compact should encourage corporate members to contribute with lessons learned from the implementation of the corporate responsibility to respect human rights. 74. The scale of the capacity-building challenge – both internal and external – is immense, and cannot be carried by one or even several entities within the United Nations system alone. Indeed, capacity-building at the necessary scale will also require the involvement and support of stakeholders outside the United Nations, as well as a careful examination of the necessary resource requirements. Lessons can be learned from other examples of global challenges requiring large-scale interventions, for example, in the area of HIV/AIDS and in improving access to immunization, where the United Nations has entered into partnership with all relevant stakeholders, including from the private sector, to create a significant capacity and funding base to enable such large-scale interventions. A similar model of public-private partnerships might be relevant for the design of a strategic response by the United Nations system to address capacity-building needs in the area of business and human rights, subject to the necessary rigorous policy safeguards in place in order to ensure the integrity of the system. 14