A/HRC/26/34 (c) Creating a global enabling environment for development that is centred on peoples and individuals. 2. States shall establish and implement appropriate mechanisms to ensure that international cooperation is based on equal partnerships and mutual commitments and obligations, where partner States are accountable to each other, as well as to their respective constituents at the national level, for the outcomes of policies, strategies and performance, whether at the bilateral, regional or international level, which shall reflect the best interests of their citizens and all others within their jurisdiction, in accordance with international human rights principles and standards. 3. States shall give effect to the establishment of a fair, inclusive and human rightsbased international trade and investment regime where all States shall act in conformity with their obligation to ensure that no international trade agreement or policy to which they are a party adversely impacts upon the protection, promotion and fulfilment of human rights inside or outside of their borders 4. International cooperation shall be targeted to the primary responsibility of each State to implement its human rights obligations on the national level, both in the immediate fulfilment of core obligations as a priority, and in the concrete, deliberate and targeted progressive realization of all human rights, including the right to development. Article 12 The right to international solidarity shall impose on States particular negative obligations, required by applicable international human rights instruments, including: (a) Not adopting free trade agreements or investment treaties that would undermine peoples’ livelihoods or other rights; (b) Not imposing conditionalities in international cooperation that would hinder or make difficult the exercise and enjoyment of human rights; (c) Not denying anyone access to life-saving pharmaceuticals and to the benefits of medical and scientific progress; (d) Not engaging in irregular weapons trading; (e) Not impeding access to information and communications technology; (f) Not increasing or contributing to global warming; (g) Not causing the depletion of or irreparable damage to natural resources; (h) Not damaging the common heritage of humankind; (i) Not undermining the rights of future generations. 23